Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
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چکیده
منابع مشابه
Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice.
Recent studies point to a major role for alpha2-containing GABA-A receptors in modulating anxiety. However, the possible implication of GABA-A receptors containing the alpha3 subunit on anxiety is less known. The aim of this study was to examine the effects of SB-205384 (0.5-4 mg/kg, i.p.), an alpha3 subunit positive modulator of GABA-A receptor, on anxiety tested in the elevated plus-maze in m...
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In the present study was examined the effect of treatment with olanzapine or risperidone, given separately or in combination with fluoxetine, in the elevated plus-maze test (an animal model of anxiety) in male Wistar rats. The obtained results showed that treatment with olanzapine (1 mg/kg), risperidone (0.1 and 0.3 mg/kg) or fluoxetine (5 and 10 mg/kg) induced an anxiolytic-like effect in the ...
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In ancient to modern system of medicine Curculigo species has been recommended for relief of different central nervous system disorders. Under this reserach study the hexane, dichloromethane, ethyl acetate, methanolic and water extracts of Curculigo orchioides root were evaluated for anxiolytic activity using Elevated Plus Maze model (EPM) and Light Dark model (LDM) in mice. The methanolic and ...
متن کاملAnxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task
Background: There are reports in traditional medicine about the effectiveness of Ocimum basilicum (OB) in the treatment of anxiety. The Elevated Plus-Maze (EPM) has been predominantly used to investigate anxiety levels in rodents. Objectives: The purpose of the present study was to investigate the effectiveness of extract of OB on rat behavior in the EPM test. Materials and Methods: Male Wistar...
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Prior test experience compromises the anxiolytic efficacy of benzodiazepines (BZs) either in rats or mice, a phenomenon not exclusive to the elevated plus-maze (EPM) animal model of anxiety, which is referred to as "one-trial tolerance." However, it remains to be determined whether a similar event occurs when testing other drugs that also possess binding-sites on the GABA(A) receptor, such as e...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2019
ISSN: 1940-087X
DOI: 10.3791/58396